Questions linger about unexplained gene-therapy trial death

Article Abstract:

Gene therapists are waiting for the outcome of investigations into the death of a participant in a pioneering gene therapy trial in Germany, expected in June 2006. One of three individuals enrolled in the trial, set to treat rare but life-threatening immunodeficiency disease chronic granulomatous disease (CGD), died on 10 April 2006 after his colon perforated and consequent septic shock caused organ failure.

Research, Germany, Clinical trials

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Biotechnology industry responds to gene therapy death

Article Abstract:

Many biotechnology companies working on gene therapy do not use adenovirus as a vector and therefore believe the death of a patient who received gene therapy will not affect them. The Arizona teenager's death from a toxic reaction to adenovirus sparked a federal investigation into gene therapy techniques.

Health aspects, Biotechnology industry, Biotechnology industries, Product information, Complications and side effects, Genetic vectors, Adenoviruses

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Reply to 'Poor trial design leaves gene therapy death a mystery'

Article Abstract:

The author disagrees with the view published in Nature Medicine magazine on Jolee Mohr's death while she was participating in a gene therapy trial. The insinuation that the trial design was inadequate is condemned.

United States, Care and treatment, Patient outcomes, Rheumatoid arthritis, Arthritics, Death of, Mohr, Jolee

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