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RBP4, an unexpected adipokine

Article Abstract:

Retinol binding protein (RBP4) is the newly discovered adipokine, which is secreted from an adipose tissue and also induces insulin resistance in the liver and skeletal muscles in addition to the delivery of retinol to the tissues. The retinoid metabolism induced by RBP4 highly affects the transactivating activity of retinoic acid as well as the metabolism of the glucose transporter GLUT4.

Author: Kasuga, Masato, Sakaue, Hiroshi, Tamori, Yoshikazu
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
Japan, Care and treatment, Type 2 diabetes, Leptin, Adipose tissues, Adipose tissue, Carotenoid metabolism, Properties

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Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-[gamma] phosphorylation

Article Abstract:

The significance of the protein downstream of tyrosine kinases-1 (Dok1) in insulin signaling and in energy homeostasis is discussed. Dok1 is found to be extremely effective in promoting high-fat diet-induced adipocyte hypertrophy and obesity in humans by modulating the peroxisome proliferator-activated receptor (PPAR)-[gamma] phosphorylation.

Author: Yamanashi, Yuji, Lazar, Mitchell A., Kasuga, Masato, Inoue, Hiroshi, Sakaue, Hiroshi, Nakamura, Takehiro, Kotani, Ko, Hosooka, Tetsuya, Noguchi, Tetsuya, Ogawa, Wataru, Tobimatsu, Kazutoshi, Takazawa, Kazuo, Sakai, Mashito, Matsuki, Yasushi, Hiramatsu, Ryuji, Yasuda, Tomoharu
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2008
Physiological aspects, Genetic aspects, Obesity, Tyrosine, Fat cells, Adipocytes, Chemical properties, Phosphotransferases

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Role of STAT - 3 in regulation of hepatic glyconeogenic genes and carbohydrate metabolism in vivo

Article Abstract:

Signal transducer and activator of transcription - 3 (STAT-3), a transcription factor contributes to various physiological processes. Hepatic STAT - 3 signaling is important for normal glucose homeostasis and for regulation of carbohydrate metabolism in vivo.

Author: Takeda, Kiyoshi, Akira, Shizuo, Kasuga, Masato, Inoue, Hiroshi, Mori, Toshiyuki, Hashimoto, Naoko; Kido, Yosiaki, Jin, Shiyu, Haga, Sanae;, Ogawa, Michitaka, Sakaue, Hiroshi, Matsumoto, Michihiro, Furukawa, Kensuke, Teshigawara, Kiyoshi
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
United States, Diabetes, Diabetes mellitus, Cellular signal transduction

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Subjects list: Research, Homeostasis
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