Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation

Article Abstract:

A monoclonal antibody called daclizumab in combination with other immunosuppressive drugs may reduce acute graft rejection in patients who have received kidney transplants. Immunosuppressive drugs decrease immune response to transplanted tissue, but can increase the risk of infection and cancer. Researchers treated 260 patients with daclizumab or placebo, in addition to standard immunosuppressive therapy. Acute rejection of the new kidney was documented in 22% of patients who received daclizumab and 35% of those receiving the placebo. Both groups had similar rates of infection and cancer.

Evaluation, Kidneys, Kidney transplantation, Immunosuppressive agents

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Prevention of rejection in cardiac transplantation by blockade of the interleukin-2 receptor with a monoclonal antibody

Article Abstract:

The drug daclizumab appears to prevent graft rejection in many patients who receive a heart transplant. This drug is a monoclonal antibody that blocks the interleukin-2 receptor on T cells. Researchers randomly assigned 55 patients receiving a heart transplant to receive daclizumab or a placebo every two weeks for a total of five doses. Graft rejection occurred in 18% of those who received daclizumab compared to 63% of those who received a placebo. Daclizumab also significantly prolonged the time to graft rejection.

Health aspects, Heart, Monoclonal antibodies, Heart transplantation

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