Redundancy of conventional articular response variables used in juvenile chronic arthritis clinical trials

Article Abstract:

A few well-chosen measurements of patients with juvenile chronic arthritis (JCA) seem to give a simpler but equally accurate assessment of disease progression as compared to the redundancy occurring in current diagnostic and monitoring practices. Researchers statistically analyzed four separate studies of 508 patients with JCA that compared the effects of one of four treatments (oral gold, D-penicillamine and hydroxychloroquine, methotrexate, or immunoglobulin) with placebo. The study researchers recorded 11 characteristics on each of 71 joints. Changes in the number of joints involved and changes in disease severity at the respective joint were statistically identical. There was a strong association between the reported changes in overall disease severity assessments and most of the other measurements made. Morning stiffness evaluations did not statistically correspond to any of the other measurements.

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Do gold rings protect against articular erosion in rheumatoid arthritis?

Article Abstract:

It appears that patients with rheumatoid arthritis (RA) who wear gold rings may have delayed disease progression in the ringed and adjacent joints. RA disease progression as measured by Larsen scores on x-ray was compared in the left ring finger joints of 30 long-term ring wearers and 25 long-term non-ring wearers. Larsen scores were lower in the left ring finger joint of ring wearers than both their own right ring finger joint and the non-ring wearers' left ring finger joint. Larsen scores were also lower in the ring wearers' left middle finger joint.

Health aspects, Prevention, Rheumatoid arthritis, Rings, Rings (Jewelry), Gold jewelry, Finger joint (Anatomy)

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Pregnancy and early onset pauciarticular juvenile arthritis

Article Abstract:

The authors examine the relationship between pregnancy and early onset pauciarticular juvenile arthritis (EOP-JCA) in a Polish population. they found that the pregnancy was successful, but after delivery, there was a flare-up of EOP-JCA particularly among women who were breast feeding.

Statistical Data Included, Diseases, Infants (Newborn), Neonatal diseases

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