Regional changes in kynurenic acid, quinolinic acid, and glial fibrillary acidic protein concentrations in the fetal sheep brain after experimentally induced placental insufficiency

Article Abstract:

The level of quinolinic acid increases in the brains of fetuses who have been exposed to low levels of oxygen and a reduced blood supply, according to a study in sheep. Quinolinic acid is toxic to nerve cells when present in excessive amounts.

Quinolinic acid

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Kynurenine production and catabolism in fetal sheep with embolized or nonembolized placentas

Article Abstract:

A placental abnormality can cause increases in kynurenic acid and quinolinic acid in the blood of the fetus, according to a study in sheep. Quinolinic acid can damage the brain, whereas kynurenic acid is believed to protect the brain.

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Tryptophan metabolism in pregnant sheep: increased fetal kynurenine production in response to maternal tryptophan loading

Article Abstract:

The fetus appears to have a greater capacity to produce kynurenine from tryptophan than its mother, according to a study in sheep. Kynurenine is believed to protect the brain from damage caused by low oxygen levels.

Fetus, Tryptophan metabolism

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