Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy

Article Abstract:

A study to show reverse signaling by soluble glucocorticoid-induced tumor necrosis factor receptor (GITR) through its natural ligand GITRL initiates the immunoregulatory pathways of tryotophan catabolism in mouse plasmacttoid dendritic cells, by means of NF-[sub.kappa.B]-dependent induction of indoleamine 2,3-dioxygenase (IDO) is made. Results show that induction of IDO could be important mechanism underlying the anti-inflammatory action of corticosteroids.

Analysis, Ligands (Biochemistry), Immune response, Immune response regulation, Tryptophan metabolism

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Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption

Article Abstract:

Early weight gain from increased total body water was observed in mice treated with Thiazolidinediones (TZDs). Weight gain was blocked by the collecting duct-specific diuretic amiloride and was also prevented by the deletion of peroxisome proliferator-activated receptor-gamma (PPARgamma) from the collecting duct.

United States, Usage, Causes of, Weight gain, Thiazolidinediones

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