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Riboswitches - to kill or save the messenger

Article Abstract:

Destroy-the-messenger approach as opposed to a save-the-messenger is used to show that by turning the riboswitch from the destruction mode to the salvage mode, gene expression can be changed from very low levels to relatively high levels. To turn the riboswitch to the salvage mode, a regulator is added that binds the self-destruction motif, allowing the messenger RNA (mRNA) to survive and be translated into protein.

Author: Sullenger, Bruce A.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
Ribosomal RNA, Genetic research

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Hepatitis B virus infection-natural history and clinical consequences

Article Abstract:

Hepatitis B virus (HBV) is a prototype member of the Hepadnaviridae family and has a strong preference for infecting liver cells. The development of a plethora of new drugs for the treatment HBV infection is detailed.

Author: Ganem, Don, Prince, Alfred M.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
Care and treatment, Virus diseases, Liver cells, Hepatocytes, Hepatitis B virus

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Subjects list: Research, United States
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