Abacavir-Lamivudine-Zidovudine vs Indinavir-Lamivudine-Zidovudine in Antiretroviral-Naive HIV-Infected Adults: A Randomized Equivalence Trial
Article Abstract:
The drug combination abacavir/lamivudine/zidovudine is equivalent to the combination indinavir/lamivudine/zidovudine in treating HIV infection, according to a study of 562 HIV patients. This is important because indinavir is a protease inhibitor, and protease inhibitors have serious side effects.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
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Safety and efficacy of lamivudine-zidovudine combination therapy in antiretroviral-naive patients: a randomized controlled comparison with zidovudine monotherapy
Article Abstract:
The combination of lamivudine and zidovudine in HIV infection appears to be more effective than zidovudine alone. A total of 129 patients were randomly allocated to take 200 milligrams (mg) of zidovudine three times a day or zidovudine plus 300 mg of lamivudine twice a day. At 24 weeks, those taking both drugs had greater increases in CD cell counts and greater decreases in blood levels of the virus. This was also true in those who switched from zidovudine alone to the drug combination.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996
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A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients: the INCAS trial
Article Abstract:
Therapy with three AIDS drugs may suppress HIV infection and prolong life. Researchers randomly assigned 151 HIV patients to take zidovudine and didanosine, zidovudine and nevirapine, or all three drugs. Although HIV blood levels dropped in all three groups, one year later, only the patients taking all three drugs consistently had low viral levels. Researchers were unable to isolate virus from 80% of those taking all three drugs, 53% of those taking zidovudine and didanosine and only 31% of those taking zidovudine and nevirapine. Triple drug therapy reduced the death rate by about half.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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