Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents

Article Abstract:

A pooled analysis of data from four double-blind trials is performed to examine the safety and the efficacy of paclitaxel- and sirolimus-eluting stents and bare-metal stents. The results have shown that stent thrombosis after 1 year was more common with both sirolimus-eluting stents and paclitaxel-eluting stents than with bare-metal stents, but there were no significant differences in the cumulative rates of death or myocardial infarction at 4 years.

General services, Safety and security measures, Clinical report

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A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease

Article Abstract:

A coronary artery stent that slowly releases the drug paclitaxel may prevent coronary arteries from becoming blocked again after angioplasty, according to a study of 1,314 patients. Angioplasty is used to open blocked arteries and then a small cylinder called a stent is placed inside the artery to keep it open. Stents that release paclitaxel substantially reduced the time it took for this to happen in this study.

Development and progression

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Comparison of a polymer-based paclitaxel-eluting stent with a bare metal stent in patients with complex coronary artery disease: A randomized controlled trial

Article Abstract:

A study investigated the safety and efficacy of the polymer-based, slow-release paclitaxel-eluting stent in a patient population with more complex lesions than previously studied. Results revealed that compared with a bare metal stent, implantation of the paclitaxel-eluting stent effectively reduces clinical and angiographic restenosis in patients with complex lesions.

Science & research, Care and treatment, Research, Clinical trials, Dosage and administration

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