Secondary dyslipidemia: inadvertent effects of drugs in clinical practice

Article Abstract:

Several classes of drugs may affect fat and cholesterol levels in the blood, which could have a positive or negative effect on patients who take them. Estrogen increases HDL cholesterol, the so-called 'good cholesterol', and decreases LDL, or 'bad' cholesterol, but it also raises triglyceride levels. Newer oral contraceptives have fewer adverse effects on cholesterol levels than old brands did. Anabolic steroids lower HDL cholesterol and raise LDL cholesterol levels. Retinoids can elevate triglycerides, and isotretinoin increases LDL cholesterol while decreasing HDL cholesterol. Corticosteroids increase the levels of all fats, including the protective HDL cholesterol. Cyclosporine A also raises total and LDL cholesterol. Phenothiazines (tranquilizers) may increase total cholesterol and decrease HDL cholesterol. Anticonvulsants raise HDL cholesterol. Many antihypertensive drugs raise triglycerides, while others raise HDL cholesterol.

Blood lipids, Lipoproteins

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Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review

Article Abstract:

An analysis of genes involved in drug metabolism can identify patients who may not metabolize drugs correctly. This information could be used to avoid a potential side effect in these patients. Of 27 drugs that most frequently cause side effects, 59% are metabolized by at least one enzyme that is known to have genetic variants.

Prevention, Genetic aspects, Drug metabolism, Medication errors

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Drug-Induced Hyperglycemia

Article Abstract:

Some drugs can increase blood sugar levels and predispose people to diabetes. Such drugs include thiazide diuretics, beta-blockers, protease inhibitors, and some antipsychotics.

Causes of, Hyperglycemia

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