Serum insulin-like growth factor binding protein profiles in postmenopausal women: their correlation with bone mineral density

Article Abstract:

Osteoporosis may be predicted in postmenopausal women through analysis of insulin-like growth factor binding protein profiles (IGFBPs) in the blood. Researchers analyzed blood from 14 postmenopausal women with osteoporosis and from 37 postmenopausal women with normal bone density for the presence of IGFBP-1, -2, -3, and -4, and osteocalcin. Women with osteoporosis had much higher levels of IGFBP-2 and osteocalcin than did normal women, but significantly lower levels of IGFBP-3. Lower concentrations of IGFBP-3 may reduce insulin-like growth factor-I levels in bone, which in turn limit activity of bone-forming cells. High levels of IGFBP-2 may damage formation of protein matrices. Both of these conditions promote osteoporosis. Lack of growth hormones may involve IGFBPs and also promote osteoporosis.

Analysis, Insulin-like growth factors, Somatomedins

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Association of vitamin D and estrogen receptor gene polymorphism with the effect of hormone replacment therapy on bone mineral density in Japanese women

Article Abstract:

Hormone replacement therapy may have little effect on bone mass in some women because they have a different version of the vitamin D receptor than other women. One of the ways estrogen strengthens bone is by stimulating the production of vitamin D. In a study of 82 Japanese women who were taking hormone replacement therapy, those with one type of vitamin D receptor experienced greater increases in bone density compared to women with another type of receptor. Genetic analysis may be needed to determine the appropriate dose of estrogen needed.

Genetic aspects, Vitamin D, Genetic polymorphisms

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Assessment by quantitative ultrasonometry of the effects of hormone replacement therapy on bone mass

Article Abstract:

Quantitative ultrasonometry may be easier and cheaper for diagnosing osteoporosis than dual-energy X-ray absorptiometry. This was the conclusion of researchers who used the technique to measure the bone mass of the heel in 2,006 menopausal women.

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