Sexual transmission of an HIV-1 variant resistant to multiple reverse-transcriptase and protease inhibitors

Article Abstract:

A case is presented of a gay man who acquired multi-drug resistant HIV from another man. He had tested negative for HIV until he developed flu-like symptoms. An HIV antibody test was negative but he tested positive on the p24 test, which measures HIV directly. He recalled having anal receptive sex without a condom with a man who had been diagnosed with HIV in 1990 and had taken nine different antiviral drugs, including protease inhibitors. The patient's virus was found to be resistant to many of the drugs and he did not respond to treatment.

Case studies, HIV (Viruses), HIV, Disease transmission, Drug resistance in microorganisms, Microbial drug resistance

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New Testing Strategy to Detect Early HIV-1 Infection for Use in Incidence Estimates and for Clinical and Prevention Purposesm, Part 3

Article Abstract:

A sensitive/less sensitive testing strategy may effectively identify patients with early HIV infection. Early HIV infection describes the period soon after HIV antibodies become detectable in the blood. Researchers tested a large number of HIV patients, AIDS patients, and blood donors for immune markers of infection. The new testing strategy correctly identified 95% of patients with early HIV infection. Identification of these patients facilitates their enrollment in studies of the development and progression of HIV.

Measurement, Development and progression, Enzyme-linked immunosorbent assay, HIV antibodies

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