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Signaling pathways for cardiac hypertrophy and failure

Article Abstract:

Research on the molecular basis of heart failure may lead to effective drug treatments for the leading cause of death in the US. Drugs that block angiotensin and endothelin receptors may prevent heart enlargement. Beta blockers can inhibit overstimulation of the neurohumoral system. Other drugs can promote contraction or relaxation of heart muscle. Drugs that inhibit cell death can prevent the death of heart muscle cells.

Author: Chien, Kenneth R., Hunter, John J.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1999
Physiological aspects, Heart enlargement, Heart hypertrophy

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Herceptin and the heart-a molecular modifier of cardiac failure

Article Abstract:

Trastuzumab, as adjuvant therapy for ErbB2-positive breast cancer was administered alone as the first agent and was not given concomitantly with or after agents known to be cardiotoxic, such as anthracyclines. With this regimen there were no recorded episodes of heart failure, and there was a negligible effect on base line cardiac function.

Author: Chien, Kenneth R.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
New England States, Risk factors, New England, Drug therapy, Combination, Combination drug therapy

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Trastuzumab - Mechanism of action and use in clinical practice

Article Abstract:

The drug Trastuzumab used in the treatment of breast cancer, its possible side effects and the need to view individual cases rather than adhere to results obtained during clinical trials are documented.

Author: Hudis, Clifford A.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
Drug overview

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Subjects list: Heart failure, Complications and side effects, Drug therapy, Breast cancer, Dosage and administration, Trastuzumab
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