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Stem-cell transplantation for high-risk breast cancer

Article Abstract:

The time to relapse may be a better method for evaluating breast cancer treatments than overall survival rates. Two studies published in 2003 on the use of high-dose chemotherapy and blood stem cell transplants for advanced breast cancer came to different conclusions. One found no difference in overall survival rates when compared to traditional chemotherapy and the other found that this treatment increased the time to relapse.

Author: Elfenbein, Gerald J.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
Editorial, Drug therapy, Lymphatic metastasis

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High-dose chemotherapy with hematopoietic stem-cell rescue for high-risk breast cancer

Article Abstract:

High-dose chemotherapy and a blood stem cell transplant may benefit some women with breast cancer that has spread to four or more lymph nodes, according to a study of 885 women. Women with cancer in four or more lymph nodes have the highest rates of relapse after traditional chemotherapy. Women who receive high-dose chemotherapy also receive a blood stem cell transplant because the chemotherapy damages their immune system.

Author: Rodenhuis, Sjoerd, Bontenbal, Marijke, Beex, Louk V.A.M., Wagstaff, John, Richel, Dick J., Nooij, Marianne A., Voest, Emile E., Hupperets, Pierre, Tinteren, Harm van, Peterse, Hans L., TenVergert, Elisabeth M., Vries, Elisabeth G.E. de
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003

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Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition

Article Abstract:

The efficacy of mammographic and MRI screening for breast cancer in women with a family history of the disease or a genetic predisposition to breast cancer is compared in this study. The study shows that the screening program used, especially MRI screening, can detect breast cancer at an early stage in women at risk for breast cancer.

Author: Klijn, Jan G.M., Zonderland, Harmine M., Beex, Louk V.A.M., Kriege, Mieke, Obdijn, Inge Marie, Manoliu, Radu A., Kok, Theu, Brekelmans, Cecile, Peterse, Hans, Tilanus-Linthorst, Madeleine M.A., Muller, Sara H., Boetes, Carla, Meijer, Sybren, Oosterwijk, Jan C., Besnard, Peter E., Tollenar, Rob A.E.M., de Koning, Harry J., Rutgers, Emiel J.T.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
Science & research, Research, Medical examination, Magnetic resonance imaging, Cancer screening

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Subjects list: Care and treatment, Evaluation, Breast cancer, Dosage and administration, Chemotherapy, Hematopoietic stem cell transplantation
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