Stress-associated preterm delivery: the role of corticotropin-releasing hormone

Article Abstract:

Stress may be one cause of premature birth and it may involve the production of corticotropin-releasing hormone. This hormone was originally found in the hypothalamus of the brain, but it is also produced by the placenta. Levels of the hormone rise substantially several weeks before birth, which stimulates the production of prostaglandins, which in turn induce labor. If this process happens earlier, it can lead to premature birth. Stress can increase the production of corticotropin-releasing hormone by the placenta, which would initiate labor and cause premature birth.

Psychological aspects, Health aspects, Stress (Psychology)

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Corticotropin-releasing hormone and the fetoplacental clock: an Australian perspective

Article Abstract:

Measuring corticotropin-releasing hormone (CRH) might be useful in predicting which pregnant women will deliver prematurely. This hormone was originally found in the hypothalamus of the brain, but it is also produced by the placenta. CRH levels in maternal blood begin to rise substantially during the last few weeks of pregnancy. Consequently, it is believed to play a role in the induction of labor. It also stimulates the fetal adrenal gland to produce cortisol, which promotes fetal maturation.

Premature labor

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A central theory of preterm and term labor: putative role for corticotropin-releasing hormone

Article Abstract:

Corticotropin-releasing hormone may be responsible for inducing labor, whether it is term or premature. This hormone is produced by the hypothalamus and ultimately stimulates the adrenal glands. Blood levels of this hormone begin to rise as a pregnant woman approaches delivery. This is believed to begin the process of labor. If the woman is under stress or has an infection, corticotropin-releasing hormone levels could rise earlier in the pregnancy, which could lead to premature birth.

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