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Subcutaneous compared with intravenous epoetin in patients receiving hemodialysis

Article Abstract:

Subcutaneous injections of epoetin rather than intravenous infusions can allow patients to receive lower doses of the costly drug. Epoetin is a synthetic version of a natural hormone that increases the production of red blood cells. Researchers evaluated both forms of administration in 208 patients with end-stage kidney disease who were on dialysis. These patients often develop anemia, which epoetin can reverse. Subcutaneous injections allowed physicians to lower the dose by 32% and 86% of those who received the injections were able to tolerate the pain of the injection.

Author: Henderson, William G., Reda, Domenic J., Kaufman, James S., Goldfarb, David S., Fye, Carol L., Kleinman, Jack G., Vaamonde, Carlos A.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
Care and treatment, Evaluation, Anemia, Injections, Hypodermic, Subcutaneous injections, Hemodialysis patients, Erythropoietin, Recombinant, Recombinant erythropoietin

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Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease

Article Abstract:

The effect of homocysteine lowering on mortality and vascular disease by the use of folic acid and B vitamins in patients with chronic and end-stage renal disease is studied. The high doses of vitamins do not show significant improvement in survival.

Author: Hartigan, Pamela, Jamison, Rex L., Kaufman, James S., Goldfarb, David S., Warren, Stuart R., Guarino, Peter D., Gaziano, Michael J.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
Health aspects, Complications and side effects, Risk factors, Drug therapy, Chronic kidney failure, Homocysteine, Clinical report

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B Vitamins for the prevention of vascular disease

Article Abstract:

A meta-analysis of observational study is planned to show the relevance of Vitamin B supplements for prevention of vascular diseases.

Author: Clarke, Robert, Baigent, Colin
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
Genetic aspects, Homocystinuria

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Subjects list: Prevention, Dosage and administration, United States, Folic acid, Blood circulation disorders, Vascular diseases, Vitamin B, Vitamin B complex
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