Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Article Abstract:

A chronic social defeat stress followed by chronic imipramine (a tricyclic antidepressant) were administered to mice and the adaptations at the levels of gene expression and chromatin remodeling of five brain-derived neurotrophic factor splice variant mRNAs (I-V) and their unique promoters in the hippocampus were studied. These experiments underscored an important role for histone remodeling in the pathophysiology and treatment of depression and highlighted the therapeutic potential for histone methylation and deacetylation inhibitors in depression.

Health aspects, Drug therapy, Depression, Mental, Depression (Mood disorder), Chromatin

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New approaches to antidepressant drug discovery: beyond monoamines

Article Abstract:

Studies have found that the tricyclic and monoamine oxidase inhibitor antidepressants promote serotonin or noradrenaline function in the brain, and though newer agents are more specific, they have the same core mechanisms of action in promoting these monoamine neurotransmitters. A summary of obstacles that have hindered the development of non-monoamine-based antidepressants is presented, along with a progress report on some of the promising current strategies.

Product development, Neurotransmitters, Monoamine oxidase

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Antidepressant actions of the exercise-regulated gene VGF

Article Abstract:

A study to identify the profile of exercise-regulated genes in the mouse hippocampus, a brain region implicated in mood and antidepressant response is conducted. Results show that administration of VGF-derived peptide produces a robust antidepressant response in mice, suggesting a new role for VGF and identifying VGF signaling as a potential therapeutic target for antidepressant drug development.

Genetic aspects, Peptides, Gene expression, Neurotrophic functions, Neurotrophins

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