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Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

Article Abstract:

The glycemic control in patients with Kir6.2 mutations who received appropriate doses of sulfonylureas are assessed and the mechanism of insulin dependence in patients who are able to switch from insulin to oral sulfonylurea therapy are examined. The results have shown that sulfonylurea therapy is safe in the short term for patients with diabetes caused by KCNJ11 mutations and is probably more effective than insulin therapy.

Author: Ashcroft, Frances M., Pearson, Eawn R., Flechter, Isabelle, Njolstad, Pal R., Malecki, Maciej T., Flanagan, Sarah E., Larkin, Brian, Klimes, Iwar, Shield, Julian, Codner, Ethel, Iotova, Violeta; Slingerland, Annabelle S., Robert, Jean-Jacques; Holst, Jens J., Clark, Penny M.; Ellard, Sian, Sovik, Oddmund; Polak, Michel; Hattersley, Andrew T.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
Care and treatment, Blood sugar, Blood glucose, Control, Insulin, Sulfonylurea compounds, Sulfonylureas, Hypoglycemic sulfonylureas

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Inhaled insulin for diabetes mellitus

Article Abstract:

A case study of a 52-year-old man with an 8-year history of diabetes mellitus is referred to an endocrinologist for evaluation of his benefit from inhaled insulin. The clinical use of the therapy, potential adverse effects and relevant formal guidelines are presented, and clinical recommendations are provided for this specific patient.

Author: Arky, Ronald A., McMohan, Graham T.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
United States, Case studies, Diabetes, Diabetes mellitus, Inhaled medication, Clinical report

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Subjects list: Health aspects
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