Targeting VEGF-A to treat cancer and age-related macular degeneration

Article Abstract:

Studies reveal that inhibiting angiogenesis is a promising approach for treating cancer and several other disorders, including intraocular neovascular syndromes. Identification of vascular endothelial growth factor (VEGF)-A as a key regulator of normal and pathological angiogenesis has facilitated significant progress toward effective treatments for such disorders, thus basic biology of VEGF-A is reviewed illustrating the clinical progress in targeting this molecule.

United States, HEALTH SERVICES, Cancer Therapy, Ambulatory Health Care Services, Health aspects, Drug therapy, Cancer, Cancer treatment, Macular degeneration, Clinical report

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Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo

Article Abstract:

A demonstration that Akt1 is the predominant isoform in vascular cells is demonstrated and the expected consequences of Akt1 knockout on the vascular integrity and pathological angiogenesis are described. Akt kinases control essential functions and are proposed as promising targets for treatment of angiogenesis-dependent pathologies such as cancer and ischemic injury.

Care and treatment, Protein kinases, Blood circulation disorders, Vascular diseases

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The biology of VEGF and its receptors

Article Abstract:

Vascular endothelial growth factor is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions and was implicated in pathological angiogenesis. The biological effects of VEGF are mediated by two receptor tyrosine kinases (RTKs) that differ considerably in signaling properties.

Influence

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