Targeting specific cell types with silencing RNA

Article Abstract:

Details of the procedure to deliver small double-stranded particles of RNA called short interfering RNA (siRNA) to certain cellular or tissue targets are presented. The resolution of specific issues related to this procedure not only makes siRNA a fundamental research tool, but renders it highly useful for drug-target validation.

Cell research, Cytological research, Drug targeting

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Targeting specific cell types with silencing RNA

Article Abstract:

Details of the procedure to deliver small double-stranded particles of RNA called short interfering RNA (siRNA) to certain cellular or tissue targets are presented. The resolution of specific issues related to this procedure not only makes siRNA a fundamental research tool, but renders it highly useful for drug-target validation.

Genetic research, RNA interference

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Small RNAs and large DNA viruses

Article Abstract:

The human cytomegalovirus (CMV) generates noncoding RNAs that allow viruses to persist by enhancing the survival of infected cells and shielding them from attack by natural killer cells. CMV uses a noncoding RNA to optimize the cellular environment for viral infection.

United States, Genetic aspects, Cytomegalovirus infections, DNA replication

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