The Relationship Between Cyclooxygenase-2 Expression and Colorectal Cancer

Article Abstract:

Measuring the amount of an enzyme called cyclooxygenase (COX-2) in tumor samples from patients with colorectal cancer may predict their prognosis. This enzyme has been linked to the development of colorectal cancer. Researchers measured the amount of the enzyme in tumor tissue samples from 76 people with colorectal cancer and 14 healthy volunteers. COX-2 was only found in the colorectal cancer patients. Patients who had high levels of COX-2 had a poor prognosis compared to those with low levels.

Colorectal cancer, Prognosis, Oxidases

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Perioperative N-acetylcysteine to prevent renal dysfunction in high-risk patients undergoing CABG surgery: A randomized controlled trial

Article Abstract:

A study is conducted to determine whether perioperative intravenous (IV) N-acetylcysteine preserves renal function in high-risk patients undergoing coronary artery bypass graft (CABG) surgery with cardiopulmonary (CPB) compared with placebo. The findings indicate that N-acetylcyteine did not prevent postoperative renal dysfunction, interventions, complications, or mortality in high-risk patients undergoing CABG surgery with CPB.

United States, Prevention, Clinical trials, Coronary artery bypass, Kidney diseases, Acetylcysteine

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Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor on pain management and recovery of function after knee replacement: a randomized controlled trial

Article Abstract:

A COX-2 inhibitor before and after surgery can reduce pain in patients who have knee replacement surgery, according to a study of 70 patients. The patients who took Vioxx had less pain and needed less physical therapy compared to those who took a placebo, or inactive substance. They were also less likely to experience nausea and vomiting or to have difficulty sleeping.

Evaluation, Product/Service Evaluation, Drug therapy, Vioxx (Medication), Rofecoxib, Pain, Postoperative, Postoperative pain, Knee replacement arthroplasty

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