The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy

Article Abstract:

Research presented concerns human immunodeficiency virus 1 (HIV-1) replication and the physiological effects of prolonged anti-retroviral therapy. Findings suggest that HIV-1 persists in patients involved in long-term anti-retroviral therapy because of the slow decay characteristics of replication-competent HIV-1.

Statistical Data Included, HIV (Viruses), HIV, Virus replication

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The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif

Article Abstract:

Research reveals that the human protein apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) has dual function in HIV pathogenesis. It can inactivate the virus by gaining entry into progeny virions, which is prevented by the HIV-1 virion infectivity factor (Vif) protein, as well as undergoes Vif induced ubiquitination and degradation by the proteasome.

United Kingdom, Prevention, Ubiquitin, Protein denaturation, Antiretroviral agents

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Latent reservoirs of HIV infection: flushing with IL-2?

Article Abstract:

It may be possible to further dilute quantitites of infectious HIV in infected people by using both potent anti-retroviral therapy and immune therapy using interleukin-2, based on recent study. Failure of potent anti-retroviral therapy to get HIV infection out may be the result of a rather small pool of infected, long-lived dormant T cells.

Health aspects, Research, T cells, Interleukin-2

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