Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy

Article Abstract:

Research presented concerns the dynamics of HIV infection after the use of highly active anti-retroviral therapy by HIV patients. Topics addressed include how the latent viral reservoir affects CD4 T cells and rebounding plasma viremia.

Viremia, CD4 lymphocytes

---

Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes

Article Abstract:

A model of HIV virus progression in rhesus monkeys is presented, focusing on the difficulties of achieving an antibody or immunological response to HIV-1 envelope proteins. Rhesus macaques were immunized with phage-displayed epitopes and evaluated for protection levels from viral challenge.

Italy, Statistical Data Included, Diseases, AIDS vaccines, Rhesus monkey

---

Effect of interleukin-2 on the pool of latently infected, resting CD4(super.+) T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy

Article Abstract:

Intermittent administration of interleukin (IL)-2 with continuous highly active anti-retroviral therapy (HAART) may lead to a substantial reduction in the pool of resting CD4(super.+) T cells containing replication-competent HIV. In a recent study it was found that virus could not be isolated from the peripheral blood CD4(super.+) T cells in three patients receiving IL-2 plus HAART. The size of the pool of resting CD4(super.+) T cells containing replication-competent HIV in the blood of patients receiving intermittent IL-2 plus HAART was significantly lower than that of patients getting only HAART.

Health aspects, Drug therapy, Interleukin-2

Similar abstracts:

• Abstracts: Micronutrient levels and HIV disease status in HIV-infected patients on highly active antiretroviral therapy in the nutrition for healthy living cohort
• Abstracts: Latent infection of CD4(super.+) T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
• Abstracts: Gamma secretase-medicated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Activin to the rescue for overexcited neurons
• Abstracts: The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Transcriptional regulation of cellular transformation

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.