Transcriptional regulation of cellular transformation

Article Abstract:

Research presented concerns the association between human neoplasms and functionally and structurally altered transcription factors. Topics addressed include transcription regulation, chromosomal translocations, and retinoic acid.

Genetic aspects, Genetic regulation, Genetic transcription, Transcription (Genetics), Tumors, Tretinoin, Genetic transformation

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The nucleolus: at the stem of immortality

Article Abstract:

This article discusses the role of nucleostemin, a nucleolar protein, in the regulation of stem and cancer cell proliferation. The protein is localized to the nucleoli of stem cells and cancer cells. Data indicate that it binds to the p53 protein and may modulate its function.

Prevention, Physiological aspects, Nucleoproteins, Cellular control mechanisms, Cell regulation, Stem cells, Cell proliferation

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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

Article Abstract:

The oncogenic effect of mTOR that cooperates with c-Myc in B-cell lymphomagene s is highlighted. Reports of c-Myc overriding eIF-4E induced cellular senescence are found.

Science & research, Care and treatment, Cancer, B cells

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