The effect of magnesium sulfate on bleeding time in pregnancy

Article Abstract:

Magnesium sulfate may cause pregnant women to bleed for longer periods of time than normal, even in the absence of blood coagulation disorders. Researchers studied 24 pregnant women who needed magnesium sulfate to prevent preterm labor and delivery, or for hypertension, to determine their bleeding times before and after magnesium sulfate infusion. Bleeding times were much longer after magnesium sulfate was administered, with normal bleeding times of 5.7 minutes and magnesium bleeding times of two hours. Magnesium sulfate is also used to treat pregnant women at risk for seizures. Magnesium has been thought to prevent platelet coagulation.

Hypertension, Measurement, Complications and side effects, Hemorrhage, Magnesium sulfate

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The induction of cyclooxygenase-2 by interleukin-4 in human umbilical vein endothelial cells: a possible role in regulation of fetal vascular tone

Article Abstract:

Interleukin-4 may influence the production of prostaglandins in the umbilical cord and alter the flow of blood to the fetus. Prostaglandins can cause blood vessels to dilate or constrict. The umbilical cord has no nerves, so regulation of blood vessel tone may rely on substances in the blood which act directly on vessel walls or umbilical tissue. Researchers incubated cells from the umbilical vein in interleukin-4 and found that it substantially increased the concentration of prostaglandin E2 and cyclooxygenase-2. These substances may regulate umbilical cord circulation.

Vascular endothelium, Umbilical cord, Interleukin-4, Prostaglandins E

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Histologic chorioamnionitis is associated with fetal growth restriction in term and preterm infants

Article Abstract:

An infection of the fetal membranes called chorioamnionitis can cause fetal growth restriction, according to a study of 2,579 fetuses with the infection and 7,732 fetuses without the infection. Fetuses born prematurely at 28 to 32 weeks were especially affected.

Health aspects, Causes of, Fetal growth retardation, Growth disorders, Chorioamnionitis

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