Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity

Article Abstract:

The mechanism of the teratogenicity of thalidomide, a sedative, has been studied. In rabbits it was found that thalidomide starts embryonic DNA oxidation and teratogenicity, but that they are stopped by pre-treatment with the free radical spin trapping agent alpha-phenyl-N-t-butylnitrone (PBN). Contrasting results were seen in mice, a species resistant to thalidomide teratogenicity. It appears that the teratogenicity of the drug may involve free radical-mediated oxidative damage to embryonic cellular macromolecules.

United States, Canada, DNA damage, Cytochemistry, Teratogenic agents, Thalidomide

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Effect of ischemia-reperfusion on xanthine oxidase activity in fetal rat brain capillaries

Article Abstract:

Low blood flow appears to stimulate enzymes that produce free radicals, which could oxidize fats in the membranes of nerve cells. This may explain why low blood flow during childbirth can lead to neurologic disability in children.

Ischemia, Lipid peroxidation

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