The heart in hypertension

Article Abstract:

Hypertensive heart disease, or heart disease caused by hypertension, is the result of increased arterial pressure and increased resistance of peripheral blood vessels. An increased workload on the heart can cause left ventricular hypertrophy, or enlargement of the left ventricle of the heart, and cardiac disorders such as congestive heart failure, irregular heart beat and ischemic heart disease. Older individuals and those with blood pressure over 160/95 have a higher risk of developing left ventricular hypertrophy than others. Left ventricular hypertrophy is caused by an increase in heart cell size and structural changes. Activation of genes that regulate cell division also occurs. Echocardiography is the most accurate method for diagnosing patients with left ventricular hypertrophy. Patients with left ventricular hypertrophy are treated with antihypertensive drugs.

Causes of, Complications and side effects

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Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass

Article Abstract:

The angiotensin-converting-enzyme (ACE) gene does not appear to significantly influence left ventricular mass or increase the genetic risk of developing an enlarged left heart heart. It has been speculated that carriers of the D allele of the ACE gene have a greater incidence for some heart disorders, especially those involving the left ventricle. DNA samples and echocardiographic data from 2,439 people were compiled and compared to identify any risk of left ventricular problems associated with the ACE gene. No difference in the prevalence of left ventricular mass or heart enlargement was found to be related to any particular genotype of the ACE gene. Further comparisons of the genotypes and polymorphic data found no relationship between the ACE locus and left ventricular mass.

Genetic aspects, Angiotensin converting enzyme

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The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report

Article Abstract:

The Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure updates the guidelines it last published in 1997 for diagnosing and treating hypertension. It incorporates compelling new evidence that thiazide diuretics are more effective than other drugs in preventing cardiovascular disease in people with high blood pressure.

Cooking, Diagnosis, Prevention, Drug therapy, Cookery for hypertensives

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