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The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

Article Abstract:

The molecular adapter Grb-2 associated binder-2 (Gab2) associates with receptor activator of NF-kB (RANK) and mediates RANK-induced activation of NF-KappaB, Akt and Jnk is reported. A new, key regulatory scaffold molecule, Gab2, that controls select RANK signaling pathways is identified and is found to be essential for osteoclastogenesis and bone homeostatis.

Author: Penninger, Josef M., Schett, Georg, Wada, Teiji, Nakashima, Tomoki, Oliveira-dos-Santos, Antonio J., Hara, Hiromitsu
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Homeostasis, Scaffolding, Receptor antibodies

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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury

Article Abstract:

Angiotensin-converting enzyme 2 (ACE2) is useful for protection against lung injury caused by severe acute respiratory syndrome coronavirus (SARS-CoV). The conversion of angiotensin II to angiotensin 1-7 by ACE2 reduces angiotensin II binding to the cell membrane receptors angiotensin II type 1a receptor (AT1aR) and angiotensin II type 2 receptor (AT2R).

Author: Penninger, Josef M., Slutsky, Arthur S., Chappell, Mark, Zhong Wang, Wada, Teiji, Rao, Shuan, Chengyu Jiang, Keiji Kuba, Yumiko Imai, Hong Gao, Feng Guo, Bin Guan, Yi Huan, Peng Yang, Yanli Zhang, Wei Deng, Linlin Bao, Binlin Zhang, Guang Liu, Yanxin Liu, Dexian Zheng, Leibbrandt, Andreas, Depei Liu, Chuan Qin
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
United States, Prevention, Risk factors, Lung diseases, Angiotensin converting enzyme, Severe acute respiratory syndrome

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The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers

Article Abstract:

Researchers have shown that the novel E3 ubiquitin ligase HACE1 is downregulated in human tumors and is mapped to a region of chromosome 6q21 implicated in multiple human cancers. The studies have shown that HCAE1 is a candidate chromosome 6q21 tumor-suppressor gene that is involved in multiple cancers.

Author: Cronin, Shane, Penninger, Josef M., Liu, Peter P., Wada, Teiji, Hara, Hiromitsu, Sarao, Renu, Liyong Zhang, Anglesio, Michael S., O'Sullivan, Maureen, Fan Zhang, Ge Yang, Nghiem, Mai P., Melnyk, Nataliya, Liheng Li, Farrar, Jason, Arceci, Robert J., Sorensen, Poul H.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
Tumor suppressor genes, Oncogenes, Tumour suppressor genes, Ubiquitin-proteasome system

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Subjects list: Research, Health aspects
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