The prognostic value of serum troponin T in unstable angina

Article Abstract:

The presence in the blood of the heart muscle protein troponin T may be a more reliable indicator of greater heart attack risk for patients with unstable angina (chest pain) than increased levels of the enzyme creatine kinase or increased creatine kinase MB activity. Troponin T is not found in the blood stream of healthy people, but is present if heart muscle cells have been damaged. Among 109 patients with unstable angina, 25 had new or subacute angina and 84 had acute angina while at rest. Of the 84 patients with acute angina, 33 (39%) had detectable blood levels of troponin T, but only three had increased creatine kinase MB activity. Ten (30%) of 33 patients with detectable blood levels of troponin T had heart attacks, and five of these patients died in the hospital. A heart attack occurred in only one of the patients with acute angina who did not have detectable blood levels of troponin T. None of the 25 patients with subacute angina had detectable levels of troponin T, and none had creatine kinase MB activity above normal.

Development and progression, Prognosis, Creatine kinase

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Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I

Article Abstract:

Bedside tests for cardiac troponin may be useful in diagnosing heart attack and unstable angina in patients with acute chest pain. Troponin T and I are proteins released into the blood when the heart muscle is deprived of bloodflow. Troponin tests were positive in 94-100% of heart attack patients and in 22-36% of unstable angina patients among 773 patients with chest pain. When the test was negative, the chance of immediate cardiac risk was low. Troponin testing may help prevent unnecessary hospitalizations for chest pain while identifying cardiac events not seen on an electrocardiogram.

Care and treatment, Diagnosis, Measurement, Chest pain

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Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels

Article Abstract:

Elevated blood levels of a protein called troponin T may indicate a patient with unstable angina who might benefit from a drug called abciximab. Abciximab blocks platelet aggregation, which would prevent blood from clotting. Of 1,265 unstable angina patients enrolled in a clinical trial of abciximab, 31% had elevated blood troponin T levels at the start of the study. In the placebo group, 24% of the patients with elevated troponin T levels had a heart attack, compared to 7% of those with normal levels. In the abciximab group, 9% of both groups had a heart attack.

Health aspects, Risk factors, Drug therapy, Monoclonal antibodies

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