The risk of recurrent venous thromboembolism in patients with an Arg506 to Gln mutation in the gene for factor V (factor V Leiden)

Article Abstract:

People who have a genetic mutation called factor V Leiden have an increased risk for recurrent venous thromboembolism. Venous thromboembolism occurs when a blood clot forms in a vein and travels to another part of the body. Researchers tested 251 people hospitalized for an episode of venous thromboembolism for the factor V Leiden mutation. Sixteen percent had the mutation and this group had more than twice the risk for a recurrent episode over the next four years compared to those without the mutation. The mutation involves the substitution of glutamine for arginine at position 506 in the factor V molecule.

Health aspects, Risk factors, Gene mutations, Gene mutation, Genetic aspects, Thromboembolism, Blood coagulation factors

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An association between atherosclerosis and venous thrombosis

Article Abstract:

Abnormal blood clot formation inside veins may be a sign of atherosclerosis even in people who don't have any symptoms of atherosclerosis. In a study of 449 people, those who had abnormal blood clot formation were twice as likely to have plaque in their carotid arteries as those who did not have abnormal blood clot formation. Plaque in the carotid arteries in the neck can be a sign of early atherosclerosis.

Causes of, Physiological aspects, Atherosclerosis, Thrombosis, Blood clot

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Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism

Article Abstract:

A study was conducted to assess the incidence of symptomatic chronic thromboembolic pulmonary hypertension (CTPH) in consecutive patients with an acute episode of pulmonary embolism. The result suggests the need for early identification and prevention of CTPH.

Science & research, Care and treatment, Research, Pulmonary embolism, Pulmonary hypertension

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