The role of nucleoside and nucleotide reverse transcriptase inhibitors backbones in antiretroviral therapy
Article Abstract:
A historical perspective on the use of NRTI backbones in the treatment of HIV infection and the advantages and disadvantages of currently available backbone combinations is described. In an environment where several NRTI/NtRTI backbones offer comparable efficacy, treatment decisions will increasingly be made based on toxicity, resistance, and convenience considerations.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
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Pharmacokinetic properties of nucleoside/nucleotide reverse transcriptase inhibitors
Article Abstract:
Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/NtRTIs) remain the backbone of highly active antiretroviral therapy (HAART). The pharmacokinetic properties, particularly those of the various phosphorylation steps, of the NRTIs/NtRTIs are reviewed.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
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New nucleoside/nucleotide backbone options: A review of recent studies
Article Abstract:
The nucleoside/nucleotide reverse inhibitor (NRTI/NtRTI) class continues to serve as an important component of the standard of care for HIV infection. Recent efficacy and safety data on emerging NRTI/NtRTI combination backbone is also summarized.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
User Contributions:
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