Increased fetal plasma prostaglandin E2 concentrations during fetal placental embolization in pregnant sheep

Article Abstract:

Prostaglandin E2 (PGE2) may rise during chronic fetal placental embolization in pregnant sheep. PGE2 is a powerful hormone-like fatty acid that regulates kidney and digestive functions, stimulates uterine contractions, and its external administration can cause abortion. Artificial embolization in the placenta involves surgically plugging the blood vessels of the fetus to restrict blood flow. Researchers measured the PGE2 levels in the fetal and maternal blood of seven embolized pregnant sheep and seven control pregnant sheep for 10 days. Embolized fetal blood contained higher levels of PGE2 on day 1, normalized thereafter, and rose again after day 7. As blood oxygen concentrations decreased, PGE2 levels rose accordingly. Early responses also included more frequent contractions of the uterus. Maternal PGE2 blood levels did not change during the experimental period. PGE2 levels may rise in the fetus to compensate and adapt to placental complications and life-threatening lack of oxygen.

Physiological aspects, Fetal anoxia, Prostaglandins E, Placental diseases, Placenta diseases

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ST segment analysis of the fetal electrocardiogram plus electronic fetal heart rate monitoring in labor and its relationship to umbilical cord arterial blood gases

Article Abstract:

Proposed to determine the ability of combined intrapartum electronic fetal heart rate monitoring plus fetal electrocardiogram ST segment automated A Nalysis (STAN) monitoring to predict metabolic acidemia by using a prospective observational cohort design. STAN clinical guidelines dictated to intervene or not to intervene has a low positive predictive value and a sensitivity of less than 50 % for metabolic acidemia at birth.

Science & research, Research, Electrocardiogram, Electrocardiography, Fetal heart rate

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Umbilical cord pH and base excess values in relation to adverse outcome events for infants delivering at term

Article Abstract:

A study was undertaken to determine the relationship of umbilical cord pH and base excess (BE) values to adverse neonatal outcomes for a large tertiary hospital population delivering at term. It is found that there is a progression of risk in term infants for Apgar less than 7 at 5 minutes and neonatal intensive care unit (NICU) admission.

United States, Observations, Fetal blood, Apgar score, Umbilical cord

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