Randomized controlled trial of the management of premenstrual syndrome and premenstrual mastalgia using luteal phase-only danazol

Article Abstract:

The drug danazol appears to be effective in treating painful breasts during the premenstrual phase. Researchers randomly assigned 100 women referred to a premenstrual syndrome clinic to take danazol or a placebo once a day from day 14 to day 28 of their period. Although the drug had no effect on most symptoms of premenstrual syndrome, it significantly alleviated breast pain in the women who took it. The drug caused few side effects. However, danazol mimics the action of male hormones, so long term use could have adverse effects.

Evaluation, Drug therapy, Premenstrual syndrome, Danazol, Mastalgia

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Abnormalities detected on transvaginal ultrasonography in tamoxifen-treated postmenopausal breast cancer patients may represent endometrial cystic atrophy

Article Abstract:

Tamoxifen may cause thickening of the endometrium as well as other endometrial disorders but this is not necessarily a sign of cancer. Researchers took biopsies of the endometrium, which is the lining of the uterus, in 35 postmenopausal women taking tamoxifen for breast cancer. All the women had a thickened endometrium, which is usually considered an abnormal feature. Twenty-three women had endometrial polyps and 10 had cystic atrophy. Both of these conditions are relatively benign. No case of endometrial cancer was detected.

Health aspects, Causes of, Complications and side effects, Postmenopausal women, Tamoxifen, Endometrial hyperplasia

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