Trisomy 21 is associated with hypercholesterolemia during intrauterine life

Article Abstract:

Fetuses with Down syndrome may have high cholesterol levels. Researchers compared cholesterol levels of 18 fetuses with trisomy 21 or Down syndrome to those of seven fetuses with trisomy 18 and 25 fetuses without trisomy, all between 18 to 36 weeks of pregnancy. Trisomy 21 fetuses had higher cholesterol and apoprotein A levels. Fetal blood testing that reveals high cholesterol levels may indicate the need for additional testing for genetic defects. Down syndrome individuals have normal cholesterol levels after birth and do not develop atherosclerosis.

Down syndrome, Hypercholesterolemia

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Serum beta2-microglobulin in fetuses with urinary tract anomalies

Article Abstract:

Increased blood levels of beta-2-microglobulin may indicate fetuses with abnormally developed urinary tracts. Researchers analyzed blood levels of beta-2-microglobulin in 53 control fetuses and in 14 fetuses with urinary tract abnormalities. All 14 fetuses with abnormalities had elevated beta-2-microglobulin levels, as did five fetuses with one dysfunctional kidney and one functional kidney. Elevated beta-2-microglobulin levels may identify a poor or nonexistent kidney filtration rate, and are related to sodium values in urine.

Health aspects, Abnormalities, Diagnosis, Fetus, Birth defects, Urinary organs, Urologic diseases, Urinary tract, Urogenital diseases

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Fetal blood sampling immediately before and within 24 hours of death in monochorionic twin pregnancies complicated by single intrauterine death

Article Abstract:

Anemia and organ damage due to blood loss may explain why a twin who survives after the death of the other twin has a poor outcome. Researchers analyzed blood samples from 8 pairs of identical twin fetuses within 24 hours of the death of one of the fetuses. Although none of the twins who died was anemic, four had high blood acid levels and three had low blood oxygen levels. However, all four survivors were anemic. This could be caused by a loss of blood to the fatally ill twin.

Patient outcomes, Mortality, Twins, Fetal death

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