A randomized trial of postoperative adjuvant therapy in patients with completely resected stage II or IIIA non-small-cell lung cancer

Article Abstract:

Chemotherapy and radiotherapy does not improve survival rates in patients with non-small-cell lung cancer compared to radiotherapy alone. This was the conclusion of a study of 488 patients who received one or the other treatment after surgery to remove most of the tumor.

Lung cancer, Non-small cell, Non-small cell lung cancer

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A meta-analysis of thoracic radiotherapy for small-cell lung cancer

Article Abstract:

Thoracic radiotherapy in combination with chemotherapy moderately improves survival rates in small-cell lung cancer patients. A statistical analysis of 13 trials and 2,103 patients with limited cases of small-cell lung cancer was conducted to assess the effectiveness of radiotherapy. There were 890 deaths among 992 patients who received chemotherapy only compared with 972 deaths among 1,111 patients who received both chemotherapy and radiotherapy. This amounts to a reduction in the risk of death of 14% for patients undergoing both therapies. Radiotherapy benefited patients under 55 years of age the most. Future studies on selecting the most effective dose of radiation, drugs given and timing of the two treatments might further improve survival rates.

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Twice-daily compared wiht once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide.`

Article Abstract:

Radiotherapy once or twice a day begun on the first cycle of chemotherapy may improve survival rates in patients with small-cell lung cancer. Researchers evaluated this treatment in 417 patients with small-cell lung cancer who were scheduled to begin chemotherapy. About half were randomly assigned to receive radiotherapy once a day and the remainder received it twice a day. Survival rates at two and five years were slightly higher in the group that received radiotherapy twice a day. However, these patients were more likely to develop an inflammation of the esophagus.

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