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Assessing tumors in living animals through measurement of urinary (Beta)-human chorionic gonadotropin

Article Abstract:

Research on methods used to evaluate internal tumors in live animals is presented. The purpose of this research is to follow cancer growth more effectively, by looking at living specimens, rather than the usual method of killing the laboratory mice at various stages of tumor development; this specific method involves the collection of urine samples to test for human chorionic gonadotropin.

Author: Kinzler, Kenneth W., Vogelstein, Bert, Ie-Ming Shih, Torrance, Christopher, Sokoll, Lori J., Chan, Daniel W.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Methods, Cancer research, Animal experimentation, Tumors, Chorionic gonadotropin, Chorionic gonadotropins

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Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

Article Abstract:

Research has been conducted on the p53 gene function. The loss of the gene's function which can occur in the colon cancer cells has been investigated and the results indicate that the apoptotic response to 5-fluorouracil has been abolished by the function.

Author: Kinzler, Kenneth W., Vogelstein, Bert, Chan, Timothy A., Hwang, Paul M., Yu, Jian, Bunz, Fred, Rago, Carlo, Murphy, Michael P., Kelso, Geoffry F., Smith, Robin A. J.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
United Kingdom, New Zealand, Analysis, Medical research, Cell death, Cancer cells, Fluorouracil

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Contribution of bone marrow-derived endothelial cells to human tumor vasculature

Article Abstract:

The role of bone marrow-derived stem cells in human tumor angiogenesis is determined by studying six individuals who developed cancers after bone marrow transplantation with donor cells derived from individuals of opposite sex. The results show substantial differences between human tumors and many mouse models with respect to angiogenesis and have major implications for the translation of experimental antiangiogenic therapies in the clinic.

Author: Lengauer, Christoph, Kinzler, Kenneth W., Vogelstein, Bert, Antin, Joseph H., Hamilton, Stanley R., Myerson, David, Polyak, Kornelia, Peters, Brock A., Guinan, Eva C., Diaz, Luis A., Jr., Meszler, Leslie, Romans, Kathy
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Science & research, Neovascularization, Cancer genetics, Stem cells

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Subjects list: Research, United States, Physiological aspects, Cancer
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