Uterine contractions after antibiotic therapy for pyelonephritis in pregnancy

Article Abstract:

Treating pregnant women who have pyelonephritis with antibiotics may cause uterine contractions, which could lead to premature delivery. Pyelonephritis is a kidney infection. Among 30 pregnant women who were treated with antibiotics for severe pyelonephritis, 29 (97%) were treated with cefazolin and one (3%) was treated with ampicillin and gentamicin. The women experienced an average of eight uterine contractions per hour one hour before beginning treatment with an antibiotic. One hour after treatment, the number of uterine contractions per hour increased, reaching a peak of 14 per hour two hours after treatment. However, this increase occurred only in the women with a gram-negative infection. Antibiotics that kill gram-negative bacteria often cause the release of bacterial toxins. The body's response to these toxins can ultimately lead to prostaglandin production, which can stimulate the uterus.

Antibiotics, Complications and side effects, Drug therapy, Uterus, Uterine contractions, Pyelonephritis

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Prolonged prior infection with Chlamydia prevents adverse pregnancy outcome in a murine model

Article Abstract:

Prior chlamydial infection before pregnancy may protect against reinfection and complications during pregnancy. Researchers infected 127 female mice with Chlamydia trachomatis, the most common human sexually transmitted disease in the US. The mice were treated with tetracycline either 7 or 30 days after infection. After treatment, the mice were mated. Long-term (30 day) Chlamydia infection was associated with greater protection from fetal death. More mothers and pups in the 7-day group were found to be positive for Chlamydia after pregnancy. Vaccination against Chlamydia may prevent pregnancy complications better than screening and treatment.

Pregnancy, Complications of, Pregnancy complications, Chlamydia infections, Chlamydia

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Chlorhexidine versus sterile water vaginal wash during labor to prevent peripartum infection

Article Abstract:

Vaginal washing with an antimicrobial agent may not lower the rate of infection in babies delivered by mothers with intrauterine infection or inflammation. Researchers administered a vaginal wash with the disinfectant, chlorhexidine, to 481 women in labor and compared its effect to that of a sterile water wash on 466 women in labor. Rates of infection did not differ significantly between women given chlorhexidine or sterile water. Twenty-five women washed with chlorhexidine had an intraamniotic infection (5.2%) versus 21 women washed with sterile water (4.5%).

Methods, Bacterial infections, Chlorhexidine, Vagina, Medication by, Vaginal medication

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