Zidovudine genotypic resistance in HIV-1-infected newborns in the French Perinatal Cohort

Article Abstract:

Many HIV-infected pregnant women may be transmitting a drug-resistant form of the virus to their baby. In a study of 34 babies born to HIV-infected mothers, 7 (20%) had a viral strain that was resistant to zidovudine (AZT). In four of these babies, it was clear that the virus came from the mother.

HIV infections, Disease transmission, Drug resistance in microorganisms, Microbial drug resistance, Pregnancy, Zidovudine, HIV infection in pregnancy

---

Neonatal characteristics in rapidly progressive perinatally acquired HIV-1 disease

Article Abstract:

All newborn infants of HIV-positive women should be tested for HIV and p24 antigen to determine if they have the rapidly progressive form of HIV infection. Researchers used data from the French Pediatric HIV Cohort, which is a network of 62 hospitals that report the results of clinical and laboratory tests on all infants born to HIV-positive mothers. A total of 1,386 children were included in the study, including 267 who had become infected. Sixty-three of the infected children developed a rapidly progressive form of the disease, which is characterized by opportunistic infections, recurrent bacterial infections, cancer and wasting syndrome within the first 12 months. Sixty-one percent of the children who developed the rapidly progressive form had been HIV positive at birth compared to 31% of those who did not. Twenty-five percent of the former group had p24 antigen in their blood compared to 5% of the latter group. Enlarged lymph nodes, liver and spleen and low CD4+ counts were also associated with the rapidly progressive form.

Development and progression, Infants (Newborn), Newborn infants

---

HIV-1 RNA detection in plasma for the diagnosis of infection in neonates

Article Abstract:

A test called nucleic acid sequence-based amplification (NASBA) appears to be as accurate as the DNA polymerase chain reaction (PCR) test for detecting clade B type HIV-1 RNA in newborns and infants. Ninety-six infants born to HIV-positive mothers were tested with both the NASBA and DNA PCR tests within 10 days of birth and again before three months of age. Of the 48 infants with identified infections at three months, 12 had a positive NASBA test at birth and 11 had a positive DNA PCR test. None of the uninfected infants were positive by either test at birth. The NASBA test is quick and requires little blood.

Diagnosis, Measurement, HIV (Viruses), HIV, Polymerase chain reaction, RNA

Similar abstracts:

• Abstracts: Zidovudine and stavudine sequencing in IHV treatment planning: findings from the CHORUS HIV cohort. Effect of persistent moderate viremia on disease progression during HIV therapy
• Abstracts: Zidovudine use in AIDS-free HIV-1 seropositive homosexual men in the Multicenter AIDS Cohort Study (MACS), 1987-1989
• Abstracts: Hemodynamic response to tibolone in reproductive and nonreproductive tissues in the sheep. Leptin in the ovine fetus correlates with fetal and placental size
• Abstracts: Incidence of invasive cervical cancer in a cohort of HIV-seropositive women before and after the introduction of highly active antiretroviral therapy
• Abstracts: Fruit and vegetable intake and population glycosylated haemoglobin levels: the EPIC-Norfolk study. Vitamin C status and respiratory function

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.