Adenosine and ATP: progress in their receptors' structures and functions

Article Abstract:

Research findings on transmembrane receptors that are activated by extracellular adenosine and ATP were presented at the 5th Annual Neuropharmacology Conference held in Oct 1997. A proposed topology for P2X receptors of two transmembrane regions consisted of a large extracellular loop and intracellular N and C termini. The loop was found to be the site for the glycosylation of the P2X receptor. Data suggest that the P2Y receptor UDP is a species homologue of the P2Y6 receptor. The conference also highlighted the neurotransmitter functions of ATP.

Cell receptors, Neurotransmitters, Adenosine

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ATP-binding cassette proteins as targets for drug discovery

Article Abstract:

ATP-binding cassette (ABC) proteins belong to a family of structurally related membrane proteins with a common intracellular motif that binds and hydrolyzes ATP. Recent findings show that sulphonylurea drugs, traditionally used in the treatment of non-insulin dependent diabetes mellitus, bind to an ABC protein to modulate insulin secretion. This discovery suggests that other ABC proteins could be pharmacological targets for future drug discovery.

Drugs, Product development, Therapeutics, Membrane proteins, Protein binding

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