Cloning and structure-function of the H2 histamine receptor

Article Abstract:

The H2 histamine receptor derived from the genomic cloning of gastric parietal cell mRNA via polymerase chain reaction represents a new monoamine receptor group exhibiting G protein activation properties. The receptor features a 359 amino acid sequence which is considerably short as compared to other G-protein receptors. However, the structural patterns of the receptor resemble those of other monoamine receptors with the exception of the two serines in the fifth transmembrane domain. Threonine and aspartate residues replace these serines causing an aspartate-imidazole-threonine interaction which is analogous to the H-bonding common to other receptors.

Histamine receptors

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Peptide G protein-coupled receptors at Erice

Article Abstract:

A conference was held in Erice, Italy, to discuss research and clinical developments related to the peptide G protein-coupled receptors (peptide GPCR). The discourse focused on drug developments, regulatory factors and the pathological significance of peptide GPCRs. The molecular properties of ligand-receptor interaction and their implications to drug development were reported. Similarly, the relevance of phosphorylation and palmitoylation in regulating GPCRs were discussed. Moreover, animal and clinical studies have identified different pharmacologic actions on various receptors.

Peptides, Proteins, Cell receptors, Peptide regulatory factors

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G-protein-coupled receptor dimers in the lime light

Article Abstract:

Laboratory evidence suggests that G-protein-coupled receptors may exist as dimers but in vivo studies will be needed to confirm this. The resonance energy transfer technique could be used to study the homo- or hetero-dimerization of GPCRs.

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