Galanin and galanin antagonists: molecular and biochemical perspectives

Article Abstract:

Galanin neuropeptides affect the endocrine, central nervous and peripheral nervous systems in different mammalian species causing the inhibition of glucose-mediated insulin release and hippocampal acetylcholine release. However, galanins facilitate the release of growth hormones in the neuroendocrine system. Moreover, the galanin receptor recognition mechanism requires the presence of the galanin 1-16 N-terminal portion which functions as a galanin receptor agonist in various processes. In addition, several synthetically prepared chimeric peptides, which exhibit different therapeutic usage, have been found to function as galanin receptor antagonists.

Somatotropin, Neuropeptides, Hippocampus (Brain), Spinal cord, Structure-activity relationship (Pharmacology)

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Designing therapeutically effective 5-lipoxygenase inhibitors

Article Abstract:

The three main classes of 5-lipoxygenase inhibitors can be therapeutically used in preventing allergic and inflammatory disorders associated with leukotriene synthesis. These inhibitors are classified as either redox, iron ligand or non-redox inhibitors depending on their precise mechanism of inhibition. Non-redox inhibitors such as ICID2138 and REV5901 promote enantiospecific interactions with the enzyme resulting in high levels of drug potency and selectivity. This mechanism has proven to be more effective than those taken by both redox and iron ligand inhibitors.

Drugs, Cover Story, Arachidonic acid, Leukotrienes, Zileuton (Medication)

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