Muscarinic receptor-mediated stimulation of adenylyl cyclase

Article Abstract:

Several investigations have shown that cAMP levels in certain cells is increased by the stimulation of PI-coupled receptors, a stimulative response which can have important implications in the study of transmembrane triggers in PI-coupled receptors. The cAMP response is unusual and probably caused indirectly by the stimulation of adenylyl cyclase in the cells. Direct coupling between PI-coupled receptors such as M1, M3 and M5 muscarinic receptors and the stimulation of adenylyl cyclase has not been observed. The cAMP response should be studied for its effect on cell growth and cellular triggering.

Investigations, Physiological aspects, Cell research, Cytological research, Adenylate cyclase, Muscarinic receptors, Muscarinic antagonists

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New insights into activation of the steroid hormone receptor superfamily

Article Abstract:

Dopamine has been found to selectively activate various members of the steroid receptor superfamily such as the A and B forms of chicken ovalbumin upstream promoter transcription factor. The dopamine activation system, which further illustrates membrane receptor-mediated phosphorylation mechanism, proceeds in a totally ligand-independent manner. However, this activation system does not affect all steroid receptors. Additionally, 8-bromo-cAMP and okadaic acid have been found to effectively imitate the activation properties of dopamine in several steroid receptor systems.

Research, Ligands (Biochemistry), Dopamine, Steroid hormones, Steroid receptors

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H3 receptor gene is cloned at last

Article Abstract:

Cloning of the gene encoding the histamine H3 receptor is discussed. Topics include homology of the H3 receptor protein with other G-protein-coupled receptors, structural features of the H3 receptor protein, receptor-ligand interactions, and H3 receptor heterogeneity.

Genetic aspects, Histamine receptors

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