New mutants to explore nicotinic receptor functions

Article Abstract:

Nicotinic receptors that are attached to ion-channels has been studied using recombinant DNA technology, affinity labelling and site-directed mutagenesis experiments. The results show that allosteric properties affect the functional behavior of these receptor-gated ion-channels. Moreover, photolabelling experiments on the mouse muscle utilizing channel blockers such as chlorpromazine and triphenylmethyl phosphonium reveal that amino acid alpha-, beta-, gamma- and delta-nicotinic acetylcholine receptor subunits have significant roles in ligand binding and ion translocation.

Analysis, Usage, Recombinant DNA, Proteins, Protein crosslinking, Ion channels, Amino acids, Mutagenesis

---

Pharmacological effects of drug conjugates: is morphine 6-glucuronide an exception?

Article Abstract:

The 6- and 3-glucuronide conjugates of morphine exhibit stronger pharmacological activity than natural morphine. Similarly, sulfate conjugates have been found to feature higher pharmacological activity than their unconjugated forms. The potency of these drugs is in contrast to the pharmacological effect that usually occurs in drug conjugates. It seems that certain factors such as receptor-drug interactions and chemical solubility affect drug conjugation processes and development with regards to the drug's chemical structure and pharmacological activity.

Drugs, Structure-activity relationships (Pharmacology), Morphine, Structure-activity relationship (Pharmacology)

---

Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors

Article Abstract:

Oocyte expression studies show that the nicotinic receptor subunit gene family can exhibit pharmacologically and functionally varied receptor-gated ion channels. The combination of the neuronal alpha and beta subunits with differential subunit stoichiometries promotes the diversification of neuronal nicotinic receptors. This subunit combination has led to the introduction of a new neuronal nicotinic receptor class which features neither specific neuronal-bungarotoxin sensitivity nor specific neuronal-bungarotoxin insensitivity.

Research, Cover Story, Electrophysiology, Oocytes, Oocyte donation

Similar abstracts:

• Abstracts: Insight into adenosine receptor function using antisense and gene-knockout approaches. Reply: a sanguine approach to cannabis
• Abstracts: Surfactants and the skin: the revival of sugar esters. Gemini surfactants
• Abstracts: D1/D2 dopamine receptor interaction at the biochemical level. Dopamine receptor partial agonists could address the duality of cocaine craving
• Abstracts: Progress in the development of potent bombesin receptor antagonists. Peptide YY and neuropeptide Y: two peptides intimately involved in electrolyte homeostasis

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.