Insight into adenosine receptor function using antisense and gene-knockout approaches

Article Abstract:

New antisense and gene-knockout methods used in studying the physiology of adenosine receptors are reviewed. The effects of adenosine are mediated through the cell-membrane spanning receptors A1, A2A, A2B and A3. The receptors have seven transmembrane domains with an extracellular carboxy terminus and an extracellular amino terminus. A series of epigenetic approaches such as RASONs and SSFGA along with genetic methods such as transgenic, gene knockout and gene therapy have shed further light on the modulation effects of these receptors.

Nucleosides, Adenosine

---

Central 5-HT(sub)1A receptors and vagal tone to the airways

Article Abstract:

This article clarifies the claim that activation of 5-HT(sub)1A receptors helps in the treatment of obstructive respiratory airway diseases. Results suggest that in animals receptor activation raises the vagal tone of the airways leading to bronchoconstriction.

Research, Nervous system, Parasympathetic, Parasympathetic nervous system, Airway obstruction (Medicine), Airway obstruction, Letter to the Editor, Parasympatholytic agents, Parasympatholytics

---

Reply: a sanguine approach to cannabis

Article Abstract:

This article clarifies the role of endocannabinoids in the treatment of multiple sclerosis. Author opines that the beneficial effects of the compounds on spasticity and tremor are transitory in nature and requires repeated administration of the drugs.

Care and treatment, Dosage and administration, Cannabis, Hamamelidae, Cannabinoids, Neurologic manifestations of general diseases, Neurologic manifestations, Spasticity

Similar abstracts:

• Abstracts: Anaesthetics in a bind? Allosteric modulation of 5-HT3 receptors: focus on alcohols and anaesthetic agents. Recent advances in the electrophysiological characterization of 5-HT3 receptors
• Abstracts: GABA(sub B) receptors make it to the top - as dimers. Responses to NMDA receptor antagonists altered by epileptogenesis
• Abstracts: Is there a 'lock' for all agonist 'keys' in 7TM receptors? Principles of agonism: undressing efficacy. The dual nature of the tachykinin NK(sub 1) receptor
• Abstracts: Cloning of a 'D3' receptor subtype expands dopamine receptor family. P2Y receptors: in the middle of the road
• Abstracts: How we describe competitive antagonists: three questions of usage. 2000 Receptor and Ion Channel Nomenclature Supplement

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.