Pharmacology in Germany

Article Abstract:

Germany served as the cradle of pharmacology in Central Europe. It started with R. Bucheim's establishment of the first pharmacologic institute in 1847. In the 19th century, F.A.W. Serturner identified morphine and other active components of medicinal plants. L. Lewin and A. Heffter isolated mescaline which served as the basis of the study of psychedelic drugs. Since then, German scientists have compiled discoveries that contributed to the development of safe and effective drugs.

History, Pharmacology, Pharmacologists

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The future of pharmacology

Article Abstract:

The emergence of innovative research methodologies has influenced the direction of pharmaceutical research and drug development in Germany. These innovations promise faster and safer drug development. Moreover, they have enabled the pharmaceutical industry to downscale its research materials and methodologies to come up with drugs that are more cost effective and target specific. The direction of pharmacology will depend on the utilization and optimization of these innovations.

Innovations, Pharmacology, Experimental, Pharmacological research

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Recent advances in the pharmacology of quaternary salts of bicuculine

Article Abstract:

Studies show the existence of a new non-gamma-aminobutyric acid (GABA)-receptor mediated action of bicuculline (BIC) salts. The new non-GABA action involves blocking of afterhyperpolarizations which are mediated by calcium-activated potassium channels in several types of neurons. Such action of BIC salts is not manifested by the base of bicuculline or other antagonists probably because of the quartenary nature of salts.

Research, Analysis, Neurotransmitters, Neurotransmitter receptors, GABA

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