What is pharmacology? A discussion
Article Abstract:
Pharmacology should be defined within its social and intellectual context. A survey of experts on the ideal definition of pharmacology reveals that most of them believe that pharmacology's main purpose is to hopefully obtain direct or indirect benefits for human beings and other selected species. Like other fields of study, pharmacology is fraught with ethical concerns particularly on respect for life in both tissues and whole organisms.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1997
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Thiopurine biology and pharmacology
Article Abstract:
The thiopurines are routinely administered to patients of various clinical conditions. After metabolism to thiopurine nucleotides, 6-mercatopurine (6-MP), azathioprine (AZA) and 6-thioguanine (6-TG) exert cytotoxicity as inactive pro-drugs. 6-MP is catabolized through xanthine oxidase and methylation catalyzed by thiopurine methyltransferase (TPMT). 6-MP serves as maintenance treatment for acute lymphoblastic leukemia.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1997
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