Of mice and flies: commonalities among 5-HT receptors

Article Abstract:

The 5-hydroxytryptamine (5-HT) receptor system is widely distributed in higher and lower vertebrates as well as in invertebrates. In many organisms, 5-HT receptors are present as multiple receptor systems with variations in structural and functional processes, and they function by modulating the levels of second messengers. The differences in receptor systems indicate that 5-HT receptors are not limited to any particular physiologic function.

Serotoninergic mechanisms

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The 5-HT(sub 7) receptor: orphan found

Article Abstract:

Research on 5-hydroxytryptamine (5-HT) has determined that 5-HT(sub 7) gene products are transmitter receptors with pharmacological functions. Gene cloning methods have been used to determine the primary structure of the receptors while operational studies have led to their classification. Research also indicate that the activation of 5-HT(sub 7) receptors increases intracellular cyclic adenylic acid like other Gs-coupled receptors.

Neurotransmitter receptors

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