The cross-talk between nitric oxide and Ca2+: a story with a complex past and a promising future

Article Abstract:

The interaction between Ca2+ and nitric oxide (NO) is not mere dependence but a true, bidirectional cross-talk. The complex interaction between the Ca2+ and NO-cGMP signalling systems present an example of Ca2+ regulated cross-talk which is continuously active at different sites. Ca2+ and NO are both involved in the control of cell homeostasis. Ca2+ levels in smooth muscles and platelets are controlled by cGMP levels. The effects of NO are also influenced by cGMP through the activation of cytosolic cGMP-dependent protein kinase 1.

Cellular control mechanisms, Cell regulation, Second messengers (Biochemistry), Second messengers (Cytochemistry), Homeostasis

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NO-aspirins: a class of new anti-inflammatory and antithrombotic agents

Article Abstract:

Nitroaspirins are a new class of anti-inflammatory agents that combine the release of nitric oxide (NO) with the inhibition of cyclooxygenase (COX). The release of NO ensures gastrointestinal safety and explains the ability of these agents to interfere with pathological processes. The toxicity of these agents, however, is largely due to the inhibition of COX, a process that helps many of the pharmacological and therapeutic effects of aspirins.

Aspirin, Fibrinolytic agents, Anti-inflammatory drugs, Anti-inflammatory agents, Thrombolytic drugs

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Nitric oxide, glial cells and neuronal degeneration in parkinsonism

Article Abstract:

Nitric oxide produced by glial cells may be responsible for destroying neurons in patients with Parkinson's disease. A drug that blocks the activity of the inducible form of nitric oxide synthase may prevent this destruction.

Nervous system, Parkinson's disease, Parkinson disease, Nerve degeneration

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