Therapeutic potential of cytokine manipulation

Article Abstract:

Control of cytokine synthesis and activity can therapeutically inhibit the adverse effects of cytokine overproduction. The cytokines, interleukin-1 and tumour necrosis factor, can be rendered ineffective through inhibition of cytokine synthesis, application of physiological antagonists and blockade of intracellular signalling. Inhibition of cytokine synthesis usually involves prevention of lipopolysaccharide-release of cytokine cells and regulation of gene transcription and translation. Receptor antagonism and intracellular signalling inhibition have proven beneficial but further developments are needed.

Health aspects, Physiological regulation, Biological control systems, Cytokines, Tumor necrosis factor

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Alzheimer's disease: pathology to potential treatments?

Article Abstract:

The study of Alzheimer's disease from a molecular pathological perspective opens new routes in the diagnosis and treatment of the disease. Genetic defects, gene mutations and environmental agents that have detrimental effects on the brain hasten the onset of the disease with the accumulation of beta/A4 amyloid plaques. The isolation of cytokine interleukin 1 (IL 1) presents a new cure for Alzheimer's disease. The endogenous IL 1 regulates nerve growth and performs other immune functions in the brain following deposition of beta/A4 plaques.

Alzheimer's disease

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Lipocortin-1 exhibits novel actions, providing clinical opportunities

Article Abstract:

Studies conducted on the action of lipocortin-1 (annexin-1) suggested that this intracellular protein group may have an important role in clinical medicine. Several researches on the action of anti-lipocortin-1 antibodies in the body provide evidences of its action as an anti-inflammatory and antipyretic agent. Testing of the protein with EDTA also showed that the protein may be found in inner and outer surfaces of the cell.

Proteins, Autocrine mechanisms

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