A supramolecular complex underlying touch sensitivity

Article Abstract:

Studies on cloning of mechanosensory-abnormal (mec) genes have determined a supramolecular complex made up of cytoskeletal, membrane, and extracellular proteins fundamental to touch sensitivity. Histological studies on mec-l and mec-5 mutants reveal the major role of the extracellular domain in mechanotransduction. Studies also indicate that mechano-gated channel protein subunits are encoded by some mec genes. Touch insensitivity is caused by recessive mutations in mec-4 while dominant mutations disintegrate touch neurons by swelling.

Research, Membrane proteins, Touch, Cytoskeletal proteins

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The pathophysiological mechanism underlying Rasmussen's encephalitis: a debate

Article Abstract:

Rasmussen's encephalitis is a pediatric neurological disorder manifested as unilateral brain inflammation associated with epileptic seizures. To date, there have been a number of hypotheses forwarded to explain the etiology and the pathophysiology of the disorder. Some researchers believe that the disease is caused by excitotoxicity-mediated neuronal death. There are those who believe that the disease is caused by complement activation while some insist that the disease is caused by a virus.

Causes of, Encephalitis

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Ambiguity and liability negotiations: the effects of the negotiator's role and the sensitivity role

Article Abstract:

The ambiguity model of Einhorn and Hogarth is examined in two experiments that analyze the role of ambiguity in liability negotiations. Results indicate that ambiguity may have a beneficial effect in negotiations by adjusting the sensitivity zone due to an adjustment in the anchor probability. With an adjustment in the sensitivity zone, there is a greater chance for settlement. Ambiguity can then influence the effectivity of a negotiator.

Psychological aspects, Models, Negotiation, Negotiations, Ambiguity

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